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It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.

Francis CrickScientist · English · 1916 – 2004
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  • If poly A is added to poly U, to form a double or triple helix, the combination is inactive. — Francis Crick
  • For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the - class as having one too few. — Francis Crick
  • Do codons overlap? In other words, as we read along the genetic message do we find a base which is a member of two or more codons? It now seems fairly certain that codons do not overlap. — Francis Crick
  • If the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it. — Francis Crick
  • Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid. — Francis Crick
  • A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here. — Francis Crick
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